Publicado sep 30, 2019



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Leila Martinez Beltrán https://orcid.org/0000-0002-5039-5106

Daniel Ozaeta Eidelman https://orcid.org/0000-0002-2795-0597

Natalia Lucía González Suárez

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Resumen

Introducción: El osteosarcoma es el tumor óseo más frecuente en los niños. La supervivencia de los que no tienen metástasis al inicio del tratamiento no ha cambiado significativamente en la última década. Existen estudios que sugieren el beneficio del uso de nuevas moléculas como mifamurtida. Métodos: Se describieron las variables de interés en 8 pacientes menores de 18 años con osteosarcoma de alto grado no metastásico, que recibieron quimioterapia convencional y mifamurtida como adyuvante en 2 instituciones de Colombia entre 2014 y 2017. Resultados: La mayoría de los pacientes tenía afectación del fémur por osteosarcoma convencional. Todos se manejaron con quimioterapia pre y posquirúrgica. El 75 % de los pacientes fue llevado a salvamento de extremidad. En total se evaluaron 375 ciclos de mifamurtida a dosis de 2 mg/m2 de superficie corporal total. Se presentaron efectos adversos en 7 de los 375 ciclos administrados (1,87 %), en 4 de los 8 pacientes participantes en el estudio. Al finalizar el estudio, 6 de los 8 pacientes estaban vivos. Conclusiones: En los pacientes evaluados, el uso de mifamurtida fue bien tolerado; sin embargo, por el tipo de estudio, no se puede determinar si el uso de este medicamento tuvo impacto en la supervivencia.

Keywords

Osteosarcoma, mifamurtide, child, survivalOsteosarcoma, mifamurtida, niño, supervivencia

References
1. Lanzkowsky P, Lipton JM, Fish JD. Manual of pediatric hematology and oncology. 6th ed. s. l.: Academic Press; 2016.
2. Pizzo PA, Poplack DG. Principles and practice of pediatric oncology. 7th ed. Philadelphia: Lippincott Williams and Wilkins; 2015.
3. Suárez A, Soto C, Gómez L, Gamboa Ó, Soto D, Escandón S, et al. Resultados del tratamiento de osteosarcoma convencional de alto grado en niños y adolescentes: análisis de supervivencia de una cohorte tratada sin metotrexato. Rev Colomb Cancerol. 2017;21(2):86-94.
4. Jimmy R, Stern C, Lisy K, White S. Effectiveness of mifamurtide in addition to standard chemotherapy for high-grade osteosarcoma. JBI Database Syst Rev Implement Reports. 2017 Aug;15(8):2113-52.
5. Goorin AM, Schwartzentruber DJ, Devidas M, Gebhardt MC, Ayala AG, Harris MB, et al. Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol. 2003;21(8):1574-80.
6. Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, et al. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): An open-label, international, randomised controlled trial. Lancet Oncol. 2016 Oct;17(10):1396-408.
7. Rosen G. Preoperative (neoadjuvant) chemotherapy for osteogenic sarcoma: A ten year experience. Orthopedics. 1985;8(5):659-64.
8. Bielack SS, Kempf-Bielack B, Winkler K. Osteosarcoma: Relationship of response to preoperative chemotherapy and type of surgery to local recurrence. J Clin Oncol. 1996;14(2):683-4.
9. Picci P, Sangiorgi L, Rougraff BT, Neff JR, Casadei R, Campanacci M. Relationship of chemotherapy-induced necrosis and surgical margins to local recurrence in osteosarcoma. J Clin Oncol. 1994;12(12):2699-705.
10. Kawai A, Healey JH, Boland PJ, Lin PP, Huvos AG, Meyers PA. Prognostic factors for patients with sarcomas of the pelvic bones. Cancer. 1998;82(5):851-9.
11. Bacci G, Bertoni F, Longhi A, Ferrari S, Forni C, Biagini R, et al. Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity. Cancer. 2003;97(12):3068-75.
12. Bacci G, Picci P, Ruggieri P, Mercuri M, Avella M, Capanna R, et al. Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. The Istituto Rizzoli Experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial cisplatin. Cancer. 1990;65(11):2539-53.
13. Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 2002;20(3):776-90.
14. Petrilli AS, de Camargo B, Filho VO, Bruniera P, Brunetto AL, Jesus-Garcia R, et al. Results of the Brazilian Osteosarcoma Treatment Group Studies III and IV: Prognostic factors and impact on survival. J Clin Oncol. 2006;24(7):1161-8.
15. Hauben EI, Weeden S, Pringle J, Van Marck EA, Hogendoorn PC. Does the histological subtype of high-grade central osteosarcoma influence the response to treatment with chemotherapy and does it affect overall survival? Eur J Cancer. 2002;38(9):1218-25.
16. Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A, Picci P. Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy. Cancer. 2006;106(5):1154-61.
17. Bishop MW, Chang Y-C, Krailo MD, Meyers PA, Provisor AJ, Schwartz CL, et al. Assessing the prognostic significance of histologic response in osteosarcoma: A comparison of outcomes on CCG-782 and INT0133-A report from the Children’s Oncology Group Bone Tumor Committee. Pediatr Blood Cancer. 2016;63(10):1737-43.
18. Bruland OS, Høifødt H, Saeter G, Smeland S, Fodstad O. Hematogenous micrometastases in osteosarcoma patients. Clin Cancer Res. 2005;11(13):4666-73.
19. Frampton JE. Mifamurtide: A review of its use in the treatment of osteosarcoma. Pediatr Drugs. 2010 Jun;12(3):141-53.
20. Meyers PA. Muramyl tripeptide (mifamurtide) for the treatment of osteosarcoma. Expert Rev Anticancer Ther. 2009 Aug 10;9(8):1035-49.
21. Anninga JK, Gelderblom H, Fiocco M, Kroep JR, Taminiau AHM, Hogendoorn PCW, et al. Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand? Eur J Cancer. 2011;47(16):2431-45.
22. Clinical Trials. Combination chemotherapy, PEG-interferon alfa 2b, and surgery in treating patients with osteosarcoma [internet]. 2015 [Citado 2011 jul 19]. Disponible en: http://www.clinicaltrials.gov/ct2/show/NCT00134030?term=AOST+0331&rank=1
23. Song HJ, Lee JA, Han E, Lee E-K. Lifetime effectiveness of mifamurtide addition to chemotherapy in nonmetastatic and metastatic osteosarcoma: a Markov process model analysis. Tumor Biol. 2015 Sep 3;36(9):6773-9.
24. Ando K, Mori K, Corradini N, Redini F, Heymann D. Mifamurtide for the treatment of nonmetastatic osteosarcoma. Expert Opin Pharmacother. 2011 Feb 13;12(2):285-92.
25. Rosen G, Marcove RC, Huvos AG, Caparros BI, Lane JM, Nirenberg A, et al. Primary osteogenic sarcoma: Eight-year experience with adjuvant chemotherapy. J Cancer Res Clin Oncol. 1983;106(S1):55-67.
26. Rosen G, Caparros B, Huvos AG, Kosloff C, Nirenberg A, Cacavio A, et al. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer. 1982;49(6):1221-30.
27. Meyers PA, Heller G, Healey J, Huvos A, Lane J, Marcove R, et al. Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience. J Clin Oncol. 1992;10(1):5-15.
28. Saeter G, Alvegård TA, Elomaa I, Stenwig AE, Holmström T, Solheim OP. Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study. J Clin Oncol. 1991;9(10):1766-75.
29. Winkler K, Beron G, Delling G, Heise U, Kabisch H, Purfürst C, et al. Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response. J Clin Oncol. 1988;6(2):329-37.
30. Souhami RL, Craft AW, Van der Eijken JW, Nooij M, Spooner D, Bramwell VH, et al. Randomised trial of two regimens of chemotherapy in operable osteosarcoma: A study of the European Osteosarcoma Intergroup. Lancet. 1997;350(9082):911-7.
31. Smeland S, Müller C, Alvegard TA, Wiklund T, Wiebe T, Björk O, et al. Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: Prognostic factors for outcome and the role of replacement salvage chemotherapy for poor histological responders. Eur J Cancer. 2003;39(4):488-94.
32. Anderson PM, Tomaras M, McConnell K. Mifamurtide in osteosarcoma - A practical review. Drugs of Today. 2010 May;46(5):327.
33. Meyers PA, Schwartz CL, Krailo MD, Healey JH, Bernstein ML, Betcher D, et al. Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children’s Oncology Group. J Clin Oncol. 2008 Feb 1;26(4):633-8.
34. Bielack SS, Marina N, Ferrari S, Helman LJ, Smeland S, Whelan JS, et al. Osteosarcoma: The Same Old Drugs or More? J Clin Oncol. 2008;26(18):3102-3.
35. Hunsberger S, Freidlin B, Smith MA. Complexities in interpretation of osteosarcoma clinical trial results. J Clin Oncol. 2008;26(18):3103-4.
Cómo citar
Martinez Beltrán, L., Eidelman, D. O., & González Suárez, N. L. (2019). Caracterización de los niños con osteosarcoma no metastásico quienes recibieron tratamiento con mifamurtida en dos instituciones de Bogotá (Colombia) entre 2014 y 2017. Universitas Medica, 60(4), 1–8. https://doi.org/10.11144/Javeriana.umed60-4.oste
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