Published Jun 15, 2010



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María Alejandra Espinosa

Mercedes Olaya Contreras

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Abstract

Infections during pregnancy are a major concern bothdue to its incidence and sequelae it might carry, including death. However, clinical suspicion of cytomegalic infection in obstetrics and pediatrics does not correlate with the low confirmation of the disease.

In the placenta, congenital CMV infection produce chronic villitis which is characterized by focal or diffuse chronic inflammation of the villi. Eighty per cent of these cases are asymptomatic, and the rest appear with severe symptoms such as neurological deficits, intrauterine growth retardation, and even death. In fetal autopsies cytomegalic inclusions are typically diagnosed in CMV infection.

We report the case of a stillbirth, product of the first pregnancy of an adolescent mother without regular prenatal control, whose autopsy showed the presence of chronic villitis. Viral inclusions in multiple organs such as lungs and pancreas were present, and CMV was confirmed by inmunohistochemestry.

Keywords

congenital infection, citomegalovirus, chronic villitis, infección congénita, citomegalovirus, villositis crónica,

References
1. Masterton R. Infection in pregnancy and the neonatal period. In: Keeling J, editor. Fetal and neonatal pathology. 3rd ed. London: Springer; 2001;323-47.
2. Ornoy A, Diav-Citrin O. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod Toxicol. 2006;21:399-409.
3. Cardona N, Gaviria M, Uribe G, Jaramillo C. Anticuerpos contra los
agentes del síndrome TORCHS en el grupo de gestantes de Medellín, Colombia. CES Med. 1987;1:27-31.
4. Anderson V. Infectious diseases. In: Gilbert-Barness E, editor. Potter´s Pathology of the fetus, infant and child. Second edition. Philadelphia: Mosby Elsevier; 2007;401-38.
5. De Albuquerque E. Cuadro clínico, laboratorial e radiológico das infecções hematogênicas no recém- nascido e suas manifestações tardias. En: Bittencourt A, editor. Infecções congênitas transplacentárias. Primera edición. Bahia: Revinter; 1995;151-80.
6. Zakyieh A, Fawza M, Nagwa A. Is low birth weight a risk indicator for congenital cytomegalovirus infection? J Infect Dev Ctries. 2010;4:44-7.
7. Camus F, Hubinot C, Bernard P. Infecciones virales. En: Gratacós E,
Gómez R, Nicolaides K, Rometo R, Cabero L, editores. Medicina fetal.
Primera edición. Madrid: Panamericana; 2007;535-58.
8. Gould S. The respiratory system. In: Keeling J, editor. Fetal and neonatal pathology. Third edition. London: Springer; 2001;441-70.
9. Greco MA. Phenotype of villous stromal cells in placentas with cytomegalovirus, syphilis, and nonspecific villitis. Am J Pathol. 1992;141:835-42.
10. Rawlinson W. Viruses and other infections in stillbirth: what is the evidence and what should we be doing? Pathology. 2008;40:149-60.
11. Khohg T. The placenta and umbilical cord. In: Keeling J, editor. Fetal and neonatal pathology. 3rd ed. London: Springer; 2001;47-92.
12. Roberts DJ. Placental pathology, a survival guide. Arch Pathol Lab Med. 2008;132:641-51.
13. La Torre R. Placental enlargement in women with primary maternal cytomegalovirus infection is associated with fetal and neonatal disease. CID. 2006;43:1001-3.
14. Kraus FT, Redline R, Gersell D, Nelson M, Dicke J. Inflammation and infection. Placental pathology. First edition. Washington, D.C.: American Registry of Pathology, Atlas of non-tumor pathology. First series, Fascicle 3; 2004;75-115.
15. Venkatesh S. Non-immune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005;25:608-11.
16. Alfonso W, Carrillo M, Jaramillo A, Sarmiento A. Chlamydia trachomatis, Citomegalovirus y herpes simple en suero y líquido amniótico de pacientes atendidas con amenaza de parto pretérmino. Fecha de consulta: Mayo 2 de 2010. Disponible en: http://www.encolombia.com/medicina/ginecologia/obstetricia51400resumenes3.htm.
17. Bermúdez A, González N, Ching R. Uso del bajo peso al nacer como criterio seleccionado para la vigilancia rutinaria de anomalías congénitas de origen infeccioso. Colombia Médica. Abril-Junio: 2008;39(2) (Supl 2), 24-8.
18. Páez M, Serrano N, Barzilai O, Ram M, Anaya J, Shoenfeld Y. Infección por citomegalovirus y virus de Epstein-Barr en pacientes con preeclampsia. Resúmenes de trabajos libres. V Congreso Mundial de Perinatología y XXVI Congreso Colombiano de Obstetricia y Ginecología. Cartagena, Colombia 2008.
How to Cite
Espinosa, M. A., & Olaya Contreras, M. (2010). A case of congenital citomegalovirus infection in San Ignacio Hospital, Bogotá. Universitas Medica, 51(3), 330–338. https://doi.org/10.11144/Javeriana.umed51-3.ccch
Section
Case Reports

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