Published May 7, 2013



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Claudia Tatiana Angarita Ribero

Lía Lorena Duitama Vergara

Martha Jimena Hurtado Sánchez

María Adelaida Córdoba Núñez

Paula Carolina Guzmán Cruz

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Abstract

Introduction: Acute lymphoblastic leukemia (ALL) is the most frequent type of cancer in children. Effective screening tests are not available, therefore appropriate and adequate diagnosis is based on the clinical and paraclinical features.

Objective: To estimate the frequency of symptoms, clinical and paraclinical signs at diagnosis in patients with ALL treated at Centro Javeriano de Oncologia. Methods: We reviewed clinical charts of ALL patients 0 to 15 years old, from October 2004 to June 2012. Frequency of specific clinical features was estimated.

Results: 54 patients were evaluated. Mucocutaneous pallor was the most frequent finding (66 %), followed by malaise (53 %). Thrombocytopenia was found in 81 % of the cases.

Conclusion: Clinical and paraclinical features suggestive of ALL, are not specific and may cause confusion of medical staff, even though knowledge of the disease and its manifestations allows correct diagnosis.

Keywords

leucemia, pediatría, diagnóstico, Leukemia, pediatrics, diagnosis,

References
1. Universidad Nacional de Colombia. Documento de alcance y objetivos: guías de atención integral 10 [internet]. Bogotá; 2011. Disponible en: http://www.guiascolcienciasminproteccionsocialalianzacinets.org/index.php?option=com_wrappe r&view=wrapper&Itemid=181.
2. Margolin J, Steuber P, Poplack D. Acute lymphoblastic leukemia. In: Pizzo PA, Poplack DC, editors. Principles and practices of pediatric oncology. 5th ed. Philadelphia: Lippinccott Williams and Wilkins; 2006. p. 538-90.
3. Piñeros M, Pardo C, Otero J, Viscaíno M, Álvarez V, Protocolo de vigilancia centinela en salud pública en leucemias agudas pediátricas. Bogotá: Instituto Nacional de Salud, Instituto Nacional de Cancerología, Ministerio de Protección Social de Colombia; 2008.
4. Pui C-H. Acute lymphoblastic leukemia. In: Pui CH, editor. Childhood leukaemia. 2nd ed. Memphis: St. Jude Children´s Research Hospital; 2006. p. 439-72.
5. Pui CH, Mullighan CG, Evans WE, Relling MV. Pediatric acute lympho-blastic leukemia: where are we going and how do we get there? Blood. 2012;120(6):1165-74.
How to Cite
Angarita Ribero, C. T., Duitama Vergara, L. L., Hurtado Sánchez, M. J., Córdoba Núñez, M. A., & Guzmán Cruz, P. C. (2013). Clinical and Paraclinical Characterization of Pediatric Patients Diagnosed with Acute Lymphoblastic Leukemia Treated at the Centro Javeriano de Oncologia (2004-2012). Universitas Medica, 54(3), 316–321. https://doi.org/10.11144/Javeriana.umed54-3.ccpp
Section
Original Articles

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