Histological Findings in Very Low Risk Prostate Cancer Patients Managed with Radical Prostatectomy

Carlos Gustavo Trujillo Ordoñez, Anamaria Ramos Hernández, Daniela Robledo Cárdenas, Ángela Marcela Mariño Álvarez, Juan Guillermo Cataño Cataño, Juan Ignacio Caicedo Cárdenas, Rebeca Escobar Monroy, Mauricio Plata Salazar



Objectives: To describe the histological findings in patients with prostate cancer (PCa) clinically classified as very low risk who underwent treatment with radical prostatectomy (RP). Material and methods: A retrospective observational study was conducted. Clinical records of patients who underwent RP between 2007-2015 who met Epstein criteria for very low risk disease were reviewed. Histological diagnosis was described and analyzed to determine if such criteria predicted very low risk. Results: A total of 609 records were reviewed; 83 (13.6%) met Epstein’s criteria. Mean age was 59 (SD±7) years and median PSA at diagnosis was 5.4 ng/dl (IQR 4.3 – 6.8). Pathology showed a median tumor volume of 4% (IQR 1 – 10%). Gleason score was 3+3 in 55 (66.3%) cases, but 28 (33.7%) were reclassified to a greater score. Two (2.4%) patients were reclassified as pT3a, 80 (96.4%) as pT2 and 1 (1.2%) was found to be pT0. In those subjected to pelvic lymphadenectomy (42.2%) no positive lymph nodes were found. Conclusions: Up to one-third of the patients clinically classified with very low risk PCa had a greater Gleason score. Only 3% had locally advanced tumors, which is comparable to previous studies. Epstein’s criteria seem to be adequate in predicting organ-confined disease. 

Palabras clave

very low risk prostate cancer;radical prostatectomy;tumor stage


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DOI: http://dx.doi.org/10.11144/Javeriana.umed58-3.risk

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