Keywords
thyroid
pathology
How to Cite
Abstract
Papillary carcinoma of the thyroid (PC) is diagnosed in most of the cases only by H&E morphology; however, the diagnosis in some cases became quite difficult, and the lesion can be over-called, for example, when the lesion has a capsule or when there are florid hyperplastic changes in goiter. And it is well known that a misdiagnosis of a PC can bring important clinical consequences. Studies have showed that immunohistochemistry can be helpful in those cases, however several markers have been proposed. We assessed expression of three marker proposed in other study (CK19, CD56 and p63) in PC and non-papillary lesions, neoplastic and non-neoplastic. 29 cases of PC were included and 31 cases on non-papillary lesions 96 % of PC were strongly positive for CK19, and 90 % were CD56 negative. Only 64 % of all PC shower focal positivity for p63. 100 % of the cases of nonpapillary lesion were strongly positive for CD56 and negative for CK19. With these results, we were able to confirm previous findings about the use of CK19 and CD56 could be useful in the cases of PC when the morphology on H&E is doubtful.
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