Dengue Virus Replication in Vertebrate and Mosquito Cells Induces Stress Responses in the Endoplasmic Reticulum and in the Golgi Complex

Abstract

Infections with dengue virus, transmitted to humans by mosquitoes of the Aedes sp. genus, constitute a public health problem for the tropical and subtropical regions of the planet. The replication cycle of dengue virus takes place mainly in the cytoplasm of cells, in close association with membranous organelles such as the rough endoplasmic reticulum and the Golgi apparatus. In this review, the response of these organelles, both in vertebrate and mosquito cells, to viral infection is analyzed and the implications of this response in the biology of these agents are discussed.