Keywords
Polimorfismo de nucleótido simple
Pruebas genéticas
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato
How to Cite
Abstract
Introduction: Gestational Diabetes (GD) is a pathology characterized for hyperglycemia during pregnancy, which generates maternal-fetal and long-term outcomes1-2. The rs9939609 polymorphism in the FTO gene could be a genetic risk factor to develop GD3, given its association with the body mass index, which has also been related to this pathology4.
Objective: To determine risk of develop GD in pregnant women from Concepción (Chile), associated with the rs9939609 polymorphism in the FTO gene.
Methods: DNA was extracted from blood samples of pregnant patients with and without DG. The rs9939609 polymorphism was genotyped by PCR-HRM. Odd Ratio (OR) was estimated with Fisher's exact test.
Results: The risk "A" allele in the rs9939609 polymorphism increases the risk of developing GD, in dominant model (OR (95% CI): 5.06 (1.29 - 19.77); p: 0.02), and in allelic model (OR (95% CI): 2.48 (1.06 - 5.79); p: 0.04). Also, carriers of the risk allele had significantly higher fasting and 2 h post-oral glucose load glycemic levels, during the second trimester of pregnancy (p: 0.03 and 0.02, respectively).
Conclusion: Women from Concepción (Chile), carriers of the risk “A” allele in the rs9939609 polymorphism, have higher risk of develop GD during pregnancy.
2 Zhang C, Olsen SF, Hinkle SN, et al. Diabetes & Women’s Health (DWH) Study: an observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark. BMJ Open. 2019; 9(4): e025517.
3 Lin Z, Wang Y, Zhang B, & Jin,Z. Association of type 2 diabetes susceptible genes GCKR, SLC30A8, and FTO polymorphisms with gestational diabetes mellitus risk: a meta-analysis. Endocrine. 2018; 62(1):34-45.
4 Chu SY, Callaghan WM, Kim SY, et al. Maternal obesity and risk of gestational diabetes mellitus. Diabetes care. 2007; 30(8): 2070-2076.
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