Abstract
Introduction: The SARS-CoV-2 infection, which causes COVID-19, affects the human population indiscriminately; the prevalence for women is close to 50%. The routes of perinatal transmission and the effects that this disease has on the placenta are not yet clear.
Objective: To histopathologically evaluate placental villi from Covid + mother with severe ARDS and non-severe pre-eclampsia at 27 weeks of gestation.
Materials and methods: Descriptive study. After signing the informed consent, a placental sample of 3 cm3 was obtained. After fixation with 10% formalin buffer for five days, it was embedded in paraffin, cut at 4 microns, and stained with hematoxylin-eosin. Image acquisition was performed with a Leica DM750 microscope.
Results: Abundant mesenchymal villi were found, indicating villous immaturity for gestational age; fetal vessel congestion, perivillous and intervillous fibrin deposits, foci of fibrinoid and hemorrhagic necrosis, mild mixed inflammatory infiltration, calcifications, and occasional nucleated erythrocytes.
Conclusions: Infection by 2019-nCoV and the systemic damage that this disease caused in the mother, impacted the maturation of villi, with evidence of hypoxia and alterations in chorionic vessels.
Conflict of interest: None
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