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Background: Although the benefit of non-pharmacological measures in treating some behavioral and cognitive symptoms of the major neurocognitive disorder is known, the documentation of the impact of multimodal interventions has not been sufficiently studied in our environment since there are no studies in Colombia that address this problem. Aim: To evaluate the effect of a multimodal intervention on the functionality, cognitive status, and quality of life of older adults with major neurocognitive disorders. Method: Descriptive study with a sample of 25 elders who attended the psychogeriatric day hospital between the years 2017-2018 and who had a Minimental State Examination greater than or equal to 10 and with the availability of a caregiver to attend follow-up meetings. A functional, cognitive, quality of life assessment and observational follow-up of stress was carried out during therapy, at the beginning of the observation, at six months, and one year. Results: No statistically significant differences were found in the functional, cognitive, or quality of life assessment; however, in all tests, a trend towards improvement was evident. A statistically significant difference was found in participants' therapy enjoyment, as measured by the NPT-ES. Conclusions: Our patients maintained their physical and cognitive functioning, had a perception of having a good quality of life, and always enjoyed their therapy. Multimodal non-pharmacological interventions are complementary to standardized therapeutic approaches and can contribute to the quality of life of the patient and her caregivers. A more significant amount of research is required in this area.
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