Cambios radiográficos después de radiocirugía/radioterapia estereotáctica corporal en cáncer de pulmón estadio I: reporte de caso
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feb 7, 2017
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Resumen
En la última década, la radioterapia estereotáctica corporal se ha implementado como tratamiento a pacientes con cáncer de pulmón estadio I, quienes son considerados inoperables o quienes rechazan el procedimiento quirúrgico. El artículo presenta el caso de uno de los primeros pacientes tratados con esta tecnología en un centro oncológico: un hombre de 72 años de edad con cáncer de pulmón estadio I, quien rechazó el manejo quirúrgico y se le realizó el tratamiento con radiocirugía, y con dos años de seguimiento, presentó cambios radiográficos, que inicialmente se interpretaron como progresión de la enfermedad. Además, se revisa la literatura relacionada con la interpretación de imágenes de seguimiento después del tratamiento.
Keywords
radiotherapy, lung carcinoma non-small cell lung consolidation, pulmonary fibrosis.radioterapia, carcinoma de pulmón de células no pequeñas, consolidación, pulmonar, fibrosis pulmonar
References
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3. Timmerman R, McGarry R, Yiannoutsos C, Papiez L, Tudor K, DeLuca J, et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24:4833-9.
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5. Mountain CF. A new international staging system for lung cancer. Chest. 1986;89:225S-33S.
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9. DeRose F, Cozzi L, Navarria P, Ascolese AM, Clerici E, Infante E, et al. Clinical outcome of stereotactic ablative body radiotherapy for lung metastatic lesions in non-small cell lung cancer oligometastatic patients. Clin Oncol. 2016;28(1):13-20. doi: 10.1016/j.clon.2015.08.011
10. Ligang X, Yong Y, Spring K. Survey of stereotactic body radiation oncology for early staged non-small cell lung cancer in china. Int J Med Phys Clin Eng Radiat Oncolo. 2014;3(1):56-9. doi: 10.4236/ijmpcero.2014.31009
11. Yu JB, Soulos PR, Cramer LD, Decker RH, Kim AW, Gross CP. Comparative effectiveness of surgery and radiosurgery for stage i non-small cell lung cancer. Cancer. 2015 Jul;121(14):2341-9. doi: 10.1002/cncr.29359
12. Verstegen NE, Lagerwaard FJ, Haasbeek CJ, et al. Outcomes of stereotactic ablative radiotherapy following a clinical diagnosis of stage I NSCLC: Comparison with a contemporaneus cohort with pathologically proven disease. Radiother Oncol. 2011;101: 250-4.
13. Nanda RH, Liu Y, Gillespie TW, Mikell JL, Ramalingam SS, Fernandez FG, et al. Stereotactic body radiation therapy versus no treatment for early stage non-small cell lung cancer in medically inoperable elderly patients: A National Cancer Data Base Analysis. Cancer. 2015;121(23):4222-30.
14. Timmerman R, Papiez L, McGarry R, et al. Extracranial stereotactic radioablation: Results of a phase I study in medically inoperable stage I non - small cell lung cancer. Chest. 2003;124:1946-55.
15. Franks P, Jain MP. Stereotactic ablative body radiotherapy for lung cancer. Clin Oncol. 2015;27:280–9.
16. Pennathur A, Luketich JD, Heron DE, Schuchert MJ, Bianco V, Clump D, Burton S. Stereotactic radiosurgery/stereotactic body radiotherapy for recurrent lung neoplasm: An analysis of outcomes in 100 patients. Ann Thorac Surg. 2015;100(6):2019-24.
17. Kelley DL, Benninghoff JS. Medically inoperable peripheral lung cancer treated with stereotactic body radiation therapy. Radiat Oncol. 2015;10:120.
18. Fukumoto S, Shirato H, Shimzu S et al. Small-volume image-guided radiotherapy using hypofractionated, coplanar, and noncoplanar multiple fields for patients with inoperable Stage I nonsmall cell lung carcinomas. Cancer. 2002;95:1546-53.
19. Timmerman R, Papiez L, McGarry R, et al. Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non - small cell lung cancer. Chest. 2003;124:1946-55.
20. Hoopes DJ, Fletcher J, Tann M, et al. A prospective trial of serial FDG-PET in patients with medically inoperable stage I non-small cell lung cancer treated with hypofractionated stereotactic body radiotherapy (SBRT). ASTRO. 2006;66:825-6.
2. Timmerman R, Paulus R, Galvin J, Michalski J, Straube W, Bradley J, et al. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA. 2010;303:1070-6.
3. Timmerman R, McGarry R, Yiannoutsos C, Papiez L, Tudor K, DeLuca J, et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24:4833-9.
4. Rowe BP, Boffa DJ, Wilson LD, Kim AW, Detterbeck FC, Decker RH. Stereotactic body radiotherapy for central lung tumors. J Thorac Oncol. 2012;7:1394-9.
5. Mountain CF. A new international staging system for lung cancer. Chest. 1986;89:225S-33S.
6. Coy P, Kennelly GM. The role of curative radiotherapy in the treatment of lung cancer. Cancer. 1980;45:698-702.
7. Chang BK, Timmerman RD. Stereotactic body radiation therapy: a comprehensive review. Am J Clin Oncol. 2007;30(6):637-44.
8. Joanne ND, Clinton M, Sanjeev S. Stereotactic body radiotherapy for centrally located early-stage non-small cell lung cancer or lung metastases from the RSSearch® patient registry. Radiation Oncol. 2015;10:113.
9. DeRose F, Cozzi L, Navarria P, Ascolese AM, Clerici E, Infante E, et al. Clinical outcome of stereotactic ablative body radiotherapy for lung metastatic lesions in non-small cell lung cancer oligometastatic patients. Clin Oncol. 2016;28(1):13-20. doi: 10.1016/j.clon.2015.08.011
10. Ligang X, Yong Y, Spring K. Survey of stereotactic body radiation oncology for early staged non-small cell lung cancer in china. Int J Med Phys Clin Eng Radiat Oncolo. 2014;3(1):56-9. doi: 10.4236/ijmpcero.2014.31009
11. Yu JB, Soulos PR, Cramer LD, Decker RH, Kim AW, Gross CP. Comparative effectiveness of surgery and radiosurgery for stage i non-small cell lung cancer. Cancer. 2015 Jul;121(14):2341-9. doi: 10.1002/cncr.29359
12. Verstegen NE, Lagerwaard FJ, Haasbeek CJ, et al. Outcomes of stereotactic ablative radiotherapy following a clinical diagnosis of stage I NSCLC: Comparison with a contemporaneus cohort with pathologically proven disease. Radiother Oncol. 2011;101: 250-4.
13. Nanda RH, Liu Y, Gillespie TW, Mikell JL, Ramalingam SS, Fernandez FG, et al. Stereotactic body radiation therapy versus no treatment for early stage non-small cell lung cancer in medically inoperable elderly patients: A National Cancer Data Base Analysis. Cancer. 2015;121(23):4222-30.
14. Timmerman R, Papiez L, McGarry R, et al. Extracranial stereotactic radioablation: Results of a phase I study in medically inoperable stage I non - small cell lung cancer. Chest. 2003;124:1946-55.
15. Franks P, Jain MP. Stereotactic ablative body radiotherapy for lung cancer. Clin Oncol. 2015;27:280–9.
16. Pennathur A, Luketich JD, Heron DE, Schuchert MJ, Bianco V, Clump D, Burton S. Stereotactic radiosurgery/stereotactic body radiotherapy for recurrent lung neoplasm: An analysis of outcomes in 100 patients. Ann Thorac Surg. 2015;100(6):2019-24.
17. Kelley DL, Benninghoff JS. Medically inoperable peripheral lung cancer treated with stereotactic body radiation therapy. Radiat Oncol. 2015;10:120.
18. Fukumoto S, Shirato H, Shimzu S et al. Small-volume image-guided radiotherapy using hypofractionated, coplanar, and noncoplanar multiple fields for patients with inoperable Stage I nonsmall cell lung carcinomas. Cancer. 2002;95:1546-53.
19. Timmerman R, Papiez L, McGarry R, et al. Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non - small cell lung cancer. Chest. 2003;124:1946-55.
20. Hoopes DJ, Fletcher J, Tann M, et al. A prospective trial of serial FDG-PET in patients with medically inoperable stage I non-small cell lung cancer treated with hypofractionated stereotactic body radiotherapy (SBRT). ASTRO. 2006;66:825-6.
Cómo citar
Sánchez Forero, R. A., Bruges Maya, R., Pérez Moreno, D., & Marín Jiménez, A. (2017). Cambios radiográficos después de radiocirugía/radioterapia estereotáctica corporal en cáncer de pulmón estadio I: reporte de caso. Universitas Medica, 57(4), 508–516. https://doi.org/10.11144/Javeriana.umed57-4.crdr
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Reportes de caso