Abstract
Hormonal changes and changes in metabolic demands occur during pregnancy with effects on thyroid function.
Objective: To evaluate maternal and neonatal TSH levels in obese pregnant women
Methods: Case-control study. Versalles Clinic. Ethics Committee 063-016. Sixty pregnant women between 18-37 years old, single pregnancy, at term (between 37-41.6 weeks). No comorbidities. Groups 1) normal weight (N): 20 women with normal BMI at the beginning of pregnancy; Gestational weight gain: between 10-13 Kg. 2) Gestational obesity (Og): 20 women with normal BMI at the beginning of pregnancy, excessive weight gain during pregnancy. Pregestational obesity (Op): BMI> 30 at the beginning of pregnancy. The thyroid profile was evaluated using a sample of maternal blood before delivery and blood from the umbilical cord.
Results: Maternal TSH did not show significant differences between the groups. However, the total T3 was higher in the Op vs N group (1.91 ± 0.06 vs 1.71 ± 0.06 ng / mL; p <0.05). Neonatal TSH was significantly lower in the Op vs N group (2.048 ± 0.138 vs 2.802 ± 0.180; p <0.05)
Conclusion: Pre-pregnancy obesity modifies maternal and neonatal HT levels and impacts on the metabolism and transport of these hormones at the placental level
2. Landers K, Richard K. Traversing barriers. How thyroid hormones pass placental, blood-brain and blood-cerebrospinal fluid barriers. Mol Cell Endocrinol. 2017;458:22-28. doi:10.1016/j.mce.2017.01.041
3. Salvatore D. Deiodinases and stem cells: an intimate relationship. J Endocrinol Invest. 2018;41(1):59-66. doi:10.1007/s40618-017-0737-4
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