Control biológico sobre Streptococcus mutans y su potencial acidogénico
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Resumen
Las acciones realizadas por instituciones de salud en la prevención de la caries dental han sido insuficientes y de bajo impacto para lograr una reducción significativa. El control biológico o terapia de remplazo, aplicado a la prevención de enfermedades infecciosas, es una posibilidad terapéutica hipotética. Sin embargo, es importante estudiar y analizar el futuro valor que pueda tener esta estrategia en la solución de problemas odontológicos, específicamente en la caries dental. El propósito de esta revisión es analizar las investigaciones realizadas en la búsqueda, mejora y aplicación de cepas de Streptococcus mutans (S. mutans) en el control biológico sobre las cepas de S. mutans nativas, y por consiguiente, en la prevención de la caries dental. En la historia del control biológico sobre S. mutans destacan los trabajos realizados por Hillman y colaboradores con cepas mutantes de S. mutans JH1001, JH1005, JH1140 y BCS3-L1. En este grupo de cepas se ha evaluado la estabilidad genética, la capacidad para colonizar y permanecer en el ambiente oral, y otras características importantes para su uso en control biológico. Los logros obtenidos en estos trabajos, unidos a la disponibilidad de técnicas de ingeniería genética, hacen pensar que se está muy cerca de conseguir la cepa de S. mutans más adecuada para realizar prevención de la caries dental.
Keywords
cavidad oral, S. mutans, cepas mutantes, terapia de remplazo, control biológico, biología molecular, DNA recombinanteoral cavity, S. mutans, mutant strains, replacement therapy, biological control, molecular biology, recombinant DNA
References
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2. Herazo B. Fluoruros. Bogotá, D. C., Colombia: Monserrate, 1988; 132-65
3. Herazo B. Antropología y epidemiología bucodental colombiana. Bogotá, D. C., Colombia:Ecoe, 1992; 297-311
4. Herazo B. Morbilidad bucodental colombiana. Bogotá, D. C., Colombia: Universidad Nacionalde Colombia, Ministerio de Salud, 1995
5. Herazo B, Moncada O. Estudio de tendencias epidemiológicas de la caries dental y las periodontopatías en menores de 14 años en grandes ciudades colombianas. Bogotá, D. C., Colombia: Pontificia Universidad Javeriana, Ministerio de Salud, 1995
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8. Rodríguez A, González OA. Fisiopatología de la caries dental. Univ Odontol 2000 May; 20(Suppl 1): 21-7
9. Hillman JD, Brooks TA, Michalek SM, Harmon CC, Snoep JL, van DerWeijden CC. Construction and characterization of an effector strain of Streptococcus mutans for replacement therapy of dental caries. Infect Immun 2000; 68: 543-49
10. McGhee JR, Michalek SM, Cassell GH. Dental Microbiology. 1st ed. Philadelphia, PA, USA: Harper and Row, 1982; 691-713
11. Negroni M. Microbiología estomatológica: fundamentos y guía práctica. 1ª ed. Buenos Aires, Argentina: Panamericana, 1999; 202-03, 211-12
12. Basson NJ. Competition for glucose between Candida albicans and oral bacteria grown in mixed culture in a chemostat. J Med Microbiol 2000; 49: 969-75
13. Mikx FHM, van der Hoeven JS, Konig KG, Plasschaert AJM, Guggenheim B. Establishment of defined microbial ecosystems in germ-free rats. I: The effect of the interaction of Streptococcus mutans or Streptococcus sanguis with Veillonella alcalescens on plaque formation and caries activity. Caries Res 1972; 6: 211-23
14. Mikx FHM, van der Hoeven JS. Symbiosis of Streptococcus mutans and Veillonella alcalescens in mixed continuous cultures. Arch Oral Biol 1975;20: 407-10
15. Tanzer JM, Freedman ML. Genetic alterations of Streptococcus mutans virulence. Adv Exp Med Biol 1978; 107: 661-72
16. Birkhed D, Tanzer JM. Glycogen synthesis pathway in Streptococcus mutans strain NCTC 104495 and its glycogen synthesis-defective mutans 805. Arch Oral Biol 1979; 24: 67-73
17. Tanzer JM, Fisher J, Freedman ML. Preemption of Streptococcus mutans 10449S colonization by its mutant 805. Infect Immun 1982; 35: 138-42
18. Hillman JD. Lactate dehydrogenase mutants of Streptococcus mutans: Isolation and preliminary characterization. Infect Immun 1978; 21: 206-12
19. Johnson CP, Gross SM, Hillman JD. Cariogenic potential in vitro in man and in vivo in the rat of lactate dehydrogenase mutants of Streptococcus mutans. Arch Oral Biol 1980; 25: 707-13
20. Abhyankar S, Sandham HJ, Chan KH. Serotype C Streptococcus mutans mutable to lactate dehydrogenase deficiency. J Dent Res 1985; 64:1267-71
21. Tanzer JM, Fisher J. Competition of a rough noncariogenic Streptococcus salivarius-like strain with Streptococcus mutans in dental plaque. In: Basic concepts of Streptococci and Streptococcal diseases. Chertsey, England: Reedbooks, 1982; 124-25
22. Tanzer JM, Kurasz AB, Clive J. Competitive displacement of mutans streptococci and inhibition of tooth decay by Streptococcus salivarius TOVE-R. Infect Immun 1985; 48: 44-50
23. Tanzer JM, Kurasz AB, Clive J. Inhibition de ecological emergence of mutans streptococci and inhibition of tooh decay by Streptococcus salivarius TOVE-R Infection. Infect Immun 1985; 49: 76-83
24. Johnson KP, Hillman JD. Competitive properties of lactate dehydrogenase mutants of the oral bacterium Streptococcus mutans in the rat. Arch Oral Biol 1982; 27: 513-16
25. Krasse B, Edwardsson S, Svensson I, Trell L. Implantation of caries-inducing streptococci in the human oral cavity. Arch Oral Biol 1967; 12: 231-36
26. Jordan HV, Englander HR, Engler WO, Kulczyk S. Observations on the implantation and transmission of Streptococcus mutans in humans. J Dent Res 1972; 51: 515-18
27. Ruangsri P, Orstavik D. Effect of the acquired pellicle and of dental plaque on the implantation of Streptococcus mutans on tooh surfaces in man. Caries Res 1977; 11: 204-10
28. Svanberg M, Loesche WJ. Implantation of Streptococcus mutans on tooth surfaces in man. Arch Oral Biol 1978; 23: 551-56
29. Svanberg M, Krasse B. Oral implantation of saliva- treated Streptococcus mutans in man. Arch Oral Biol 1981; 26: 197-201
30. Berkowitz RJ, Jordan HV, White G. The early establishment of Streptococcus mutans in the mouths of infants. Arch Oral Biol 1975; 20: 171-74
31. Carlsson J, Grahnén H, Jonsson G. Lactobacilli and Streptococci in the mouth of children. Caries Res 1975; 9: 333-39
32. Kohler B, Bratthall D, Krasse B. Preventive measures in mothers influence the establishment of the bacterium Streptococcus mutans in their infants. Arch Oral Biol 1983; 28: 225-31
33. Weerkampp A, Bongaerts-Larik L, Vogels G.D. Bacteriocins as factors in the in vitro interaction between oral streptococci in plaque. Infect Immun 1977; 16: 773-80
34. Rogers AH, van der Hoeven JS, Mikx FH. Effect of Bacteriocin production by Streptococcus mutans on the plaque of gnotobiotic rats. InfectImmun 1979; 23: 571-76
35. van der Hoeven JS, Rogers AH. Stability of the resident microflora and the bacteriocinogeny of Streptococcus mutans as factors affecting its establishment in specific pathogen-free rats. Infect Immun 1979; 23: 206-12
36. Hillman JD, Johson KP, Yaphe BI. Isolation of a Streptococcus mutans strain producing a novel bacteriocin. Infect Immun 1984; 44: 141-44
37. Hillman JD, Yaphe BI, Johnson KP. Colonization of the human oral cavity by a strain of Streptococcus mutans. J Dent Res 1985; 64: 1272-74
38. Hillman JD, Dzuback AL, Andrews SW. Colonization of the human oral cavity by a Streptococcus mutans mutant producing increased bacteriocin. J Dent Res 1987; 66: 1092-94
39. Chen A, Hillman JD, Duncan M. L-(+)-Lactate dehydrogenase deficiency is lethal in Streptococcus mutans. J Bacteriol 1994; 176: 1542-45
40. Hillman JD, Chen A, Snoep JL. Genetic and physiological analysis of the lethal effect of L- (+) – lactate dehydrogenase deficiency in Streptococcus mutans: Complementation by alcohol dehydrogenase from Zymomonas mobilis. Infect Immun 1996; 64: 4319-23
2. Herazo B. Fluoruros. Bogotá, D. C., Colombia: Monserrate, 1988; 132-65
3. Herazo B. Antropología y epidemiología bucodental colombiana. Bogotá, D. C., Colombia:Ecoe, 1992; 297-311
4. Herazo B. Morbilidad bucodental colombiana. Bogotá, D. C., Colombia: Universidad Nacionalde Colombia, Ministerio de Salud, 1995
5. Herazo B, Moncada O. Estudio de tendencias epidemiológicas de la caries dental y las periodontopatías en menores de 14 años en grandes ciudades colombianas. Bogotá, D. C., Colombia: Pontificia Universidad Javeriana, Ministerio de Salud, 1995
6. República de Colombia, Ministerio de Salud. III Estudio Nacional de Salud Bucal -ENSAB III-. Bogotá, D. C., Colombia: El Ministerio, Centro Nacional de Consultoría, 1999
7. Herazo B, Castro M, Castro E, Ceballos M, Del Río L. Control biológico del Streptococcus mutans. Clinical O 1989; 1: 180-7
8. Rodríguez A, González OA. Fisiopatología de la caries dental. Univ Odontol 2000 May; 20(Suppl 1): 21-7
9. Hillman JD, Brooks TA, Michalek SM, Harmon CC, Snoep JL, van DerWeijden CC. Construction and characterization of an effector strain of Streptococcus mutans for replacement therapy of dental caries. Infect Immun 2000; 68: 543-49
10. McGhee JR, Michalek SM, Cassell GH. Dental Microbiology. 1st ed. Philadelphia, PA, USA: Harper and Row, 1982; 691-713
11. Negroni M. Microbiología estomatológica: fundamentos y guía práctica. 1ª ed. Buenos Aires, Argentina: Panamericana, 1999; 202-03, 211-12
12. Basson NJ. Competition for glucose between Candida albicans and oral bacteria grown in mixed culture in a chemostat. J Med Microbiol 2000; 49: 969-75
13. Mikx FHM, van der Hoeven JS, Konig KG, Plasschaert AJM, Guggenheim B. Establishment of defined microbial ecosystems in germ-free rats. I: The effect of the interaction of Streptococcus mutans or Streptococcus sanguis with Veillonella alcalescens on plaque formation and caries activity. Caries Res 1972; 6: 211-23
14. Mikx FHM, van der Hoeven JS. Symbiosis of Streptococcus mutans and Veillonella alcalescens in mixed continuous cultures. Arch Oral Biol 1975;20: 407-10
15. Tanzer JM, Freedman ML. Genetic alterations of Streptococcus mutans virulence. Adv Exp Med Biol 1978; 107: 661-72
16. Birkhed D, Tanzer JM. Glycogen synthesis pathway in Streptococcus mutans strain NCTC 104495 and its glycogen synthesis-defective mutans 805. Arch Oral Biol 1979; 24: 67-73
17. Tanzer JM, Fisher J, Freedman ML. Preemption of Streptococcus mutans 10449S colonization by its mutant 805. Infect Immun 1982; 35: 138-42
18. Hillman JD. Lactate dehydrogenase mutants of Streptococcus mutans: Isolation and preliminary characterization. Infect Immun 1978; 21: 206-12
19. Johnson CP, Gross SM, Hillman JD. Cariogenic potential in vitro in man and in vivo in the rat of lactate dehydrogenase mutants of Streptococcus mutans. Arch Oral Biol 1980; 25: 707-13
20. Abhyankar S, Sandham HJ, Chan KH. Serotype C Streptococcus mutans mutable to lactate dehydrogenase deficiency. J Dent Res 1985; 64:1267-71
21. Tanzer JM, Fisher J. Competition of a rough noncariogenic Streptococcus salivarius-like strain with Streptococcus mutans in dental plaque. In: Basic concepts of Streptococci and Streptococcal diseases. Chertsey, England: Reedbooks, 1982; 124-25
22. Tanzer JM, Kurasz AB, Clive J. Competitive displacement of mutans streptococci and inhibition of tooth decay by Streptococcus salivarius TOVE-R. Infect Immun 1985; 48: 44-50
23. Tanzer JM, Kurasz AB, Clive J. Inhibition de ecological emergence of mutans streptococci and inhibition of tooh decay by Streptococcus salivarius TOVE-R Infection. Infect Immun 1985; 49: 76-83
24. Johnson KP, Hillman JD. Competitive properties of lactate dehydrogenase mutants of the oral bacterium Streptococcus mutans in the rat. Arch Oral Biol 1982; 27: 513-16
25. Krasse B, Edwardsson S, Svensson I, Trell L. Implantation of caries-inducing streptococci in the human oral cavity. Arch Oral Biol 1967; 12: 231-36
26. Jordan HV, Englander HR, Engler WO, Kulczyk S. Observations on the implantation and transmission of Streptococcus mutans in humans. J Dent Res 1972; 51: 515-18
27. Ruangsri P, Orstavik D. Effect of the acquired pellicle and of dental plaque on the implantation of Streptococcus mutans on tooh surfaces in man. Caries Res 1977; 11: 204-10
28. Svanberg M, Loesche WJ. Implantation of Streptococcus mutans on tooth surfaces in man. Arch Oral Biol 1978; 23: 551-56
29. Svanberg M, Krasse B. Oral implantation of saliva- treated Streptococcus mutans in man. Arch Oral Biol 1981; 26: 197-201
30. Berkowitz RJ, Jordan HV, White G. The early establishment of Streptococcus mutans in the mouths of infants. Arch Oral Biol 1975; 20: 171-74
31. Carlsson J, Grahnén H, Jonsson G. Lactobacilli and Streptococci in the mouth of children. Caries Res 1975; 9: 333-39
32. Kohler B, Bratthall D, Krasse B. Preventive measures in mothers influence the establishment of the bacterium Streptococcus mutans in their infants. Arch Oral Biol 1983; 28: 225-31
33. Weerkampp A, Bongaerts-Larik L, Vogels G.D. Bacteriocins as factors in the in vitro interaction between oral streptococci in plaque. Infect Immun 1977; 16: 773-80
34. Rogers AH, van der Hoeven JS, Mikx FH. Effect of Bacteriocin production by Streptococcus mutans on the plaque of gnotobiotic rats. InfectImmun 1979; 23: 571-76
35. van der Hoeven JS, Rogers AH. Stability of the resident microflora and the bacteriocinogeny of Streptococcus mutans as factors affecting its establishment in specific pathogen-free rats. Infect Immun 1979; 23: 206-12
36. Hillman JD, Johson KP, Yaphe BI. Isolation of a Streptococcus mutans strain producing a novel bacteriocin. Infect Immun 1984; 44: 141-44
37. Hillman JD, Yaphe BI, Johnson KP. Colonization of the human oral cavity by a strain of Streptococcus mutans. J Dent Res 1985; 64: 1272-74
38. Hillman JD, Dzuback AL, Andrews SW. Colonization of the human oral cavity by a Streptococcus mutans mutant producing increased bacteriocin. J Dent Res 1987; 66: 1092-94
39. Chen A, Hillman JD, Duncan M. L-(+)-Lactate dehydrogenase deficiency is lethal in Streptococcus mutans. J Bacteriol 1994; 176: 1542-45
40. Hillman JD, Chen A, Snoep JL. Genetic and physiological analysis of the lethal effect of L- (+) – lactate dehydrogenase deficiency in Streptococcus mutans: Complementation by alcohol dehydrogenase from Zymomonas mobilis. Infect Immun 1996; 64: 4319-23
Cómo citar
Gamboa Jaimes, F. O., Martínez Pabón, M. C., & Herazo Acuña, B. (2021). Control biológico sobre Streptococcus mutans y su potencial acidogénico. Universitas Odontologica, 24(54-55), 144–150. Recuperado a partir de https://revistas.javeriana.edu.co/index.php/revUnivOdontologica/article/view/13598
Sección
Ciencias Básicas, Biotecnología y Bioinformática
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.