Abstract
This study was aimed to analyse pregnancy complications after a sublethal infection with Salmonella Enteritidis (SE) during late gestation. BALB/c pregnant mice were treated at day 14 of gestation with streptomycin and 24 h later they received 103 CFU of SE intragastrically. At day 3 post infection bacterial loads, intestinal permeability and placental histomorphometry were analysed. Results showed that intestinal permeability to FITC-dextran was increased in infected mothers in comparison to virgin infected mice and non infected pregnant females (p<0.05). This finding was correlated to a substantial bacterial colonization of spleen, uterus placenta and fetuses. Infected placentas showed significant macroscopic changes in placental thickness, surface area, and placental coefficient versus controls (p <0.05). On the contrary, microscopic measurements of labyrinth zone area and thickness, did not show alterations. Histological evaluation of placentas was performed. Placental infected tissue showed foci of necrosis accompanied by acute leukocyte infiltration in decidua. In contrast, fetal zones showed normal histomorphological characteristics. In summary, a low dose of SE during late stages of pregnancy resulted in impaired intestinal permeability leading to massive infection of the maternal organs and the feto-placental unit.
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