Linfoma primario del sistema nervioso central de la fosa posterior en un paciente joven
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nov 28, 2010
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Resumen
El linfoma primario del sistema nervioso central es una neoplasia rara que se encuentra con relativa frecuencia en pacientes con inmunosupresión.
Se presenta el caso de una mujer de 38 años sin antecedentes relevantes, a quien se le resecó un tumor del ángulo ponto-cerebeloso izquierdo, cuya anatomopatología reportó un linfoma B de célula grande muy maligno. Se hicieron estudios en busca de inmunosupresión, los que fueron negativos. La paciente no se encontraba en el rango de edad de presentación de este tipo de tumor y sólo estudios moleculares genéticos podrían dar alguna explicación a este caso.
Keywords
linfoma primario, ángulo pontocerebeloso, sistema nervioso central, primary lymphoma, cerebellopontine angle, central nervous system,
References
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2. Chimienti E, Spina M, Vaccher E, Tirelli U. Management of immunocompetent patients with primary central nervous system lymphoma. Clin Lymphoma Myeloma. 2009;5:353-64.
3. Batchelor T, Loeffler JS. Primary CNS lymphoma. J Clin Oncol. 2006;24:1281-8.
4. Rubenstein J, Ferreri A, Pitaluga S. Primary lymphoma of the central
nervous system: Epidemiology, pathology and current approaches to
diagnosis, prognosis and treatment. Leuk Lymphoma. 2008;49(Suppl.1):43-51.
5. Olson JE, Janney CA, Rao RD, Cerhan JR, Kurtin PJ, Schiff D, et al. The
continuing increase in the incidence of primary central nervous system non-Hodgkin lymphoma: A surveillance, epidemiology, and end results analysis. Cancer. 2002;95:1504-10.
6. Mohile N, Abrey L. Primary central nervous system lymphoma. Neurol
Clin. 2007;25:1193-207.
7. van der Valk P. Central nervous system lymphomas. Curr Diagn Pathol. 1996; 3:45-52.
8. Jahnke K, Hummel M, Korfel A, Burmeister T, Kiewe P, Klasen HA,
Müller HH, Stein H, Thiel E.. Detection of subclinical systemic disease in
primary CNS lymphoma by polymerase chain reaction of the rearranged immunoglobulin heavy chain genes. J Clin Oncol. 2006;24:4754-7.
9. Koga H, Zhang S, Ichikawa T, Washiyama K, Kuroiwa T, Tanaka R,
Kumanishi T. Primary malignant lymphoma of the brain: Demonstration
of the p53 gene mutations by PCRSSCP analysis and immunohistochemistry. Brain Tumor Pathol. 1994;11:151-5.
10. Ferreri AJ, Reni M, Pasini F, Calderoni A, Tirelli U, Pivnik A, et al. A
multicenter study of treatment of primary CNS lymphoma. Neurology.
2002;58:1513-20.
11. Ferreri AJ, Abrey LE, Blay JY, Borisch B, Hochman J, Neuwelt EA, et al. Summary statement on primary central nervous system lymphomas from the Eighth International Conference on Malignant Lymphoma, Lugano, Switzerland, June 12 to 15, 2002. J Clin Oncol. 2003;21:2407-14.
12. Abrey L, Yahalom J, De Angelis L. Treatment for primary CNS lymphoma: The next step. J Clin Oncol. 2000; 18:3144-50.
Cómo citar
Roldán, T., Zorro, Óscar, Villalobos, L. M., & Rodríguez, L. M. (2010). Linfoma primario del sistema nervioso central de la fosa posterior en un paciente joven. Universitas Medica, 52(1), 112–119. https://doi.org/10.11144/Javeriana.umed52-1.lpsn
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